A prospective study on outcomes of heat stable carbetocin vs. Oxytocin on prevention of postpartum haemorrage

Abstract

Background: Postpartum haemorrhage contributes 27% of all maternal fatalities that occur globally each year and 14 million women worldwide suffer with postpartum bleeding annually. Objective: To study the efficiency of heat stable carbetocin over the oxytocin in the prevention of the postpartum haemorrhage. Patients and methods: This study included 130 women and were assigned into two groups of 65 patients: Group 1 includes carbetocin single dose recipients of 100ug- IM in vaginal delivery and 100ug-IV in caesarean delivery, administered slowly for 1minute and Group 2 includes oxytocin drug recipients of 10IU-IV, infused in 500(ml) of Nacl solution, administered for about 15- 60 minutes until desired dilatation and 10IU-IM after child birth. Results: Regarding predelivery haemoglobin and HCT, there was no statistically significant difference and postdelivery there was statistically significant differences between the two study groups. There was significant increase in frequency of blood transfusion and need of additional uterotonic drugs in oxytocin group regard to carbetocin group. There was statistically significant increase pain perception in oxytocin group than carbetocin group. There was statistically significant increased incidence of pruritus in carbetocin group than oxytocin group. There was statistically significant increase in frequency of nausea, vomiting, sweating in oxytocin group compared to carbetocin group. There was significant increase in frequency of elevated temperature in carbetocin group compared to oxytocin group. Conclusion: Carbetocin has the non- inferiority effect on oxytocin for prevention of postpartum haemorrhage.