Formulation and Characterization of Transdermal Drug Delivery System of Losartan Potassium

Abstract

The aim of present work is to fabricate and characterize the transdermal patches of Losartan potassium by using HPMC K 100, Carbopol 934 and Eudragit RL 100 as a polymers with following objectives such as design and evaluated results of present investigation revealed that, Suitable analytical method based on UV-Visible spectrophotometer was developed for Losartan Potassium λ_max of 205 nm was identified in phosphate buffer, pH 7.4. All the excipients used did not interfere with the estimation of Losartan Potassium at analytical wavelength 205 nm respectively. Transdermal patches of Losartan Potassium were successfully prepared using HPMC K100, Eudragit RL100 and Carbopol 934 as polymers by Solvent casting Technique. The formulation L8 (2% HPMC, 1% CP) has shown optimum and high percentage of drug release (99.21%) in concentration independent manner. Hence, transdermal patch of Losartan Potassium could be promising drug delivery as they minimize the dose, overcome the side effects, simplify treatment regimen and improve patient compliance. The present investigation is worthy of further research, especially in terms of performance in pharmacokinetics, In-vivo studies on higher animals and controlled clinical studies on human beings.