Development and Evaluation of Ophthalmic Drug Delivery System for Glaucoma

Abstract

This study aimed to develop ocuserts of Pefloxacin mesylate using various polymers (PVA, HPMC, PVP, and HEC) through solvent casting. The resulting films were smooth and transparent, although variations in thickness were observed. The formulation PD3, containing HEC, demonstrated high moisture absorption, while PA1 exhibited moisture loss. The ocuserts had a thickness ranging from 0.14±0.022mm to 0.225±0.045mm and weights from 10.14±0.12mg to 17.25±0.11mg. In vitro drug release studies of PD3 indicated prolonged release, with approximately 47.2% of the drug released within 12 hours, following zero-order kinetics. Ex vivo studies of PD3 showed a release of approximately 51.3%. The developed ocuserts displayed controlled release properties and uniform characteristics, suggesting their potential as an effective ophthalmic delivery system for Pefloxacin mesylate, reducing dosing frequency and improving patient compliance.