Preparation and Characterization of Naringin Loaded Chitosan Nanoparticles

Abstract

The present study involves the formulation, optimisation and evaluation of naringin loaded chitosan nanoparticles by ionotropic gelation method using sodium tripolyphosphate as ionic cross-linker. Five nanoparticulate formulations of nanoparticles were prepared and evaluated for various parameters like particle size, zeta potential, % yield,% drug content,% entrapment efficiency, surface morphology, drug-polymer compatibility studies include (FTIR,DSC) and in vitro dissolution studies. The particle size and zeta potential of optimised formulation was found to be 352.4 nm, -31.5 mV respectively. SEM analysis revealed that the particles were of spherical in shape having smooth surface. The drug-polymer compatibility studies depicted that there was no interaction of between drug and polymer. The % entrapment efficiency was in the range of 47.4% to 69.7 %. In vitro dissolution studies showed highest % release for optimised formulation (92.0%) in 24 hrs. Kinetic modelling revealed that the drug release followed first order kinetics. The results obtained from this study proved that chitosan nanoparticles are potential candidates for drug delivery of naringin with enhanced bioavailability, safety and efficacy.