Development and Ev Aluation of Lns Loded Topical Ointment of Amoroifine by QBD Approach

Abstract

This research work investigates the dissolvability of tetrahydrocannabinol in different excipients and its formulation into lipid nanoparticles (LNs) for enhanced drug delivery. THC showed the highest solubility in olive oil, but solid lipid nanoparticles (SLNs) were formulated using Tween 80 as the surfactant for improved solubilization and stabilization. A pseudoternary phase diagram optimized excipient concentrations, ensuring stable formulations. DLS demonstrated optimalsize of particle& PDI for effective skin penetration, while zeta potential analysis indicated stability through steric and reduced electrostatic stabilization. High-resolution transmission electron microscopy (HRTEM) and nanoparticle tracking analysis (NTA) confirmed uniform, consistent particle sizes. Spectroscopic analyses (DSC,FTIR) &XRD validated the amorphous nature of THC within the formulations. Central Composite Design (CCD) optimization yielded a reliable model, showing strong potential for improving THC bioavailability in therapeutic applications.