Design and optimization of gastro retentive bilayer floating tablet of Dexlansoprazole

Abstract

This study focuses on the formulation and evaluation of Dexlansoprazole floating tablets, aimed at achieving prolonged gastric retention and controlled drug release. A UV spectrophotometric analysis confirmed the linearity of Dexlansoprazole’s calibration curve (2-10 µg/ml) with an excellent correlation coefficient (R²=0.9997). Precompression evaluations, demonstrated good flow and compressibility. Post-compression results confirmed tablet uniformity, mechanical strength (hardness 5.01–5.69 kg/cm²), low friability (<1%), and consistent drug content (98%-102%). In-vitro buoyancy studies revealed most formulations exhibited rapid floating within 20-80 seconds, maintaining buoyancy for up to 12 hours. In-vitro dissolution profiles showed controlled drug release over 12 hours, with the F2 formulation exhibiting the best release pattern. Drug release kinetics of F2 followed the Higuchi model (R² = 0.974), indicating diffusion-controlled release with non-Fickian transport (n = 0.503). FT-IR studies confirmed no significant interactions b/w the drug and excipients. Overall, the F2 formulation was identified as optimal for its buoyancy and sustained drug release properties.