Phytochemical Screening and Pharmacological evaluation of anti-ulcer activity of ethanolic extract of Pistia stratiotes

Abstract

Peptic ulcer is the most common, chronic gastrointestinal disorder and has become a common global health problem affecting a large number of people worldwide and still a major cause of morbidity and mortality. The anti-ulcer activity of ethanolic extract of Pistia stratiotes (araceae) leaves of EEPS was investigated in pylorus ligation and ethanol-induced ulcer models in Wistar rats. In this model, the parameter determined was ulcer index EEPS at doses of 200,400 mg/kg p.o produced significant inhibition of the gastric lesions induced by pylorus ligation-induced ulcers. The extract (200, 400 mg/kg) showed a significant (P < 0.001) reduction in gastric volume, free acidity and ulcer index as compared to the control. This present study indicates that Pistia stratiotes leaves extract has potential antiulcer activity. These results may further suggest that ethanolic extract was found to possess antiulcer genic as well as ulcer healing properties.