Formulation and Evaluation of Controled Release Tablets of Efonidipine

Abstract

This study aimed to develop and evaluate controlled-release (CR) tablets of Efonidipine, focusing on calibration curve construction and tablet property assessment. Calibration curves were established in Acid media(0.1N hydrochloric acid) and Potassium Buffer having pH-6.8, with absorbance measured at 271 nm and 270 nm, respectively, showing excellent linearity (R² = 0.999) in the 2 to 10 µg/ml concentration range. Pre-compression studies indicated good flow properties, with Carr’s index (≤ 18%) and Hausner’s ratio (1.09-1.21) within acceptable limits, and an angle of repose between 22.17° and 31.11°. Post-compression evaluations confirmed consistent tablet weights, thickness (5.82-5.91 mm), hardness (5.9-6.3 kg/cm²), friability (<1%), and drug content within 98-102%. In vitro dissolution studies conducted in 0.1N HCl and 6.8 sodium phosphate buffer showed significant drug release over 12 hours, with varying profiles across formulations. Kinetic modeling using zero-order, first-order, Higuchi, and Korsmeyer-Peppas plots indicated diverse release mechanisms, with most formulations demonstrating anomalous transport. These results suggest that the Efonidipine CR tablets have potential for controlled drug delivery applications.