Formulation and Evaluation of Microparticle Controlled Release Solid Dosage Form of Lobeglitazone

Abstract

This research work focuses on the advancement & evaluation of Lobeglitazone controlled-release (CR) tablets, specifically assessing their pre- & post-compression characteristics, alongside dissolution profiles in 6.8 phosphate buffer. A standard CC graph for Lobeglitazone was established by measuring absorbance at 231 nm, confirming compliance with the conc. extent of 2 to 10µg per ml, with a regression value of 0.999 indicating high correlation. Pre-compression evaluations revealed good flow properties, with bulk & tapped densities being nearly uniform across formulations. Post-compression studies showed that the tablets maintained an acceptable weight variation, thickness (5.80 to 5.90 mm), & hardness (5.9 to 6.3 kg per cm²), with friability under 1%. The in-vitro disso studies demonstrated that the tablets released the drug effectively over 12 hours. Kinetic analysis of the dissolution data suggested a combination of zero-order and first-order release mechanisms, contributing to the formulation's potential for controlled drug delivery.