Effect of Lindane to enzyme activity in the tissues of Liver, Muscle and Brain of freshwater fish, Cyprinus carpio

Abstract

The wide spread use of synthetic organic pesticides over decades has let to their frequent exposure in the environment. Also acute and chronic exposures of humans to pesticides occur during their commercial production and their application. Synthetic pesticides are deliberately sprayed on crops or agricultural land to increase food production but these agrochemicals are not very selective in producing their effects. They are toxic to many non-target species and contaminate the environment. Hence, a need was felt to investigate a effect of sublethal exposure of Organ chlorine pesticide Lindane to enzyme content of GOT, GPT, ALP, ACP and LDH in the liver, muscle and brain of freshwater fish Cyprinus carpio. At the end of each exposure period, fishes were sacrificed and tissues were removed and analyzed for enzyme activity. It was found that GOT, GPT and LDH increased to the maximum level (after Lindane exposure) when compared to the controls (100%) and ACP,ALP were decreased from the control at 10, 20 and 30 days in the liver, muscle and brain, respectively at LC₅₀ exposure. The median lethal concentration was found to be 0.32 ppm.