Journal of Pharmaceutical and Biological Research
type: channel
publisher: Pharma Research Library
language: en
publication name: Journal of Pharmaceutical and Biological Research
issn: 2347-8330
items: Pharmacoeconomics in India: Comparative Assessment of Cost-effectiveness, Policy Implications and Adoption of Best Practices from Developed and Brazil, Russia, India, China, South Africa Countries.
items: Effect of Superdisintegrants on Theophylline Pellets Prepared by Extrusion–Spheronization Technique
items: Evaluation and Characterization of Losartan and Hydrochlorothiazide fixed dose as Gastroretentive bilayered floating tablets
items: Stability Studies of Optimized Formulation of Losartan and Hydrochlorothiazide Bilayer Floating Tablets
items: Study of Effect of Various Polymers in the Formulation Development of Mucoadhesive Buccal Tablets of Propranolol HCL
items: Design and Characterization of Lansoprazole Delayed Release Tables Employing Novel Entric Coating Agents
items: Artificial Intelligence in Pharmaceutical Regulatory Compliance: Data Integrity, AI Validation, and Digital QA Systems
items: Development and Evaluation of Fast Dissolving Tablets of Pravastatin by Enhancing Dissolution Rate and Bioavailability
items: Assay Technologies in Pharmaceutical and Biomedical Sciences: Principles, Classification, Validation, and Emerging Innovations
items: Formulation and Evaluation of Polyherbal Dosage Form Exhibiting Anti Acne Activity
items: Bacterial Biofilm Formation on Infant Pacifiers and Its Impact on Feeding Habits: Evaluation of the Antimicrobial Activity of Selected Plant Extracts
items: Preparation and Evaluation of Herbal Cream Formulated from Calotropis gigantea Leaves
items: A Review on Ebola Virus Disease and Its Prevention and Management in Community
items: Plant-Based Multifunctional Nutraceuticals as Preventive Interventions for Modern Lifestyle Disorders
items: Investigation of Antidiabetic Activity and Antioxidant Activity of Moringa Oleifera in Rats
items: Analytical Method Development and Validation of Chloro Impurity and Methyl Ester Impurity by Using RP-HPLC
items: Therapeutic strategies on Blood brain barrier
items: Investigation of Anti-Ulcer Activity of Triticum Aestivum in Rats
items: Current Appraisal Procedures for New Regulations, Standards, Policies, and Guidance Issued by Regulatory Authorities
items: Analytical Method Development and Validation for the Simultaneous Estimation of Gabapentin and Nortriptyline by RP-HPLC method
items: Design, Development and Validation of Bioanalytical Methods for Pharmaceutical Formulations – Review
items: A Review on Satellite DNA
items: Art Therapy: A Scientific Review
items: Water cure Therapy: A Review
items: Effect of Hydroalcoholic Extract of Orthosiphon Thymiflorus Leaves on Glycemia of Diabetic Rats
items: Formulation of Mucoadhesive Microspheres of Irbesartan and Their Evaluation
items: A study on traditional medicinal plants of Pillur Beat (Pillur slope RF and Nellithurai RF), Karamadai range, Coimbatore district, Tamil Nadu.
items: Medicinal Plants Diversity in Kundri Hill T.N Palayam Range of Sathyamangalam Reserve Forest in Erode District, Tamil Nadu
items: A Comparative Safety and Efficacy Study of Olmesrtan, a Newer Angiotensin-II Type-1 Receptor Blocker in Early Stage Type–2 Diabetes with Hypertension
items: Evaluation of Cardioprotective Activity of Ethanolic Extract of Cordia sebestena Against Myocardial Infarction: A Comprehensive Review

Pharmacoeconomics in India: Comparative Assessment of Cost-effectiveness, Policy Implications and Adoption of Best Practices from Developed and Brazil, Russia, India, China, South Africa Countries.
type: item
description: This study offers an in-depth, policy-oriented and analytically driven evaluation of Pharmacoeconomics within the Indian healthcare system. It integrates a structured review of both domestic and international evidence with a comparative examination of health technology assessment mechanisms and pharmaceutical pricing policies in developed economies and BRICS nations, including the United States, United Kingdom, and Canada. A bespoke decision-analytic framework, based on an oncology Markov model, is developed to assess cost-effectiveness and financial impact across multiple pricing and reimbursement scenarios. The analysis estimates anticipated health outcomes alongside fiscal implications associated with the adoption of selected policy instruments, such as strengthened HTA processes through HTAIn, value-based pricing approaches, managed entry agreements, and formalized price negotiation strategies adapted to India’s institutional environment and inter-state diversity in healthcare delivery. The study further outlines actionable policy pathways, supported by an implementation framework detailing timelines, resource needs, and performance indicators. Comprehensive references and supplementary appendices, including model specifications, parameter inputs, and stakeholder consultation tools, accompany the manuscript.
subject: Articles
  topic: section
subject: Pharmacoeconomics
  topic: keywords
subject: cost-effectiveness
  topic: keywords
subject: HTA
  topic: keywords
subject: India
  topic: keywords
subject: HTAIn
  topic: keywords
subject: NPPA
  topic: keywords
subject: value-based pricing
  topic: keywords
subject: PM-JAY
  topic: keywords
subject: NICE
  topic: keywords
subject: CADTH
  topic: keywords
creator: Guntaka Ramachandra Reddy
creator: Deepa. N
creator: Benita.E
creator: Janani.P
creator: Kirubakaran.A
creator: Shahana.S
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-07-06
publication date: 2026-07-06
starting page: 54
ending page: 57
doi: 10.30904/j.jpbr.2026.4988

Effect of Superdisintegrants on Theophylline Pellets Prepared by Extrusion–Spheronization Technique
type: item
description: The present study was carried out to investigate the effect of superdisintegrants on the drug release characteristics of Theophylline pellets prepared by the extrusion–spheronization technique. Theophylline was selected as a model drug, while microcrystalline cellulose (MCC) was used as the primary pelletizing aid. Three superdisintegrants, namely sodium starch glycolate (Primojel), croscarmellose sodium (Ac-Di-Sol), and crospovidone (Polyplasdone XL10), were incorporated to evaluate their influence on pellet characteristics and dissolution behaviour. Pellets were prepared using suitable granulating liquids and binders, and their physical properties, including particle size distribution, shape, flow properties, friability, drug content, disintegration, and in-vitro dissolution, were evaluated. The prepared pellets exhibited good sphericity with circularity values ranging from 0.968 to 1.00, excellent flow characteristics, low friability (<0.1%), and drug content within acceptable limits (89.06–98.89%). All formulations disintegrated within 30 minutes, with croscarmellose sodium-containing pellets showing faster disintegration than sodium starch glycolate formulations. The incorporation of superdisintegrants significantly enhanced drug release compared to pellets containing only MCC. The dissolution behaviour was found to depend on the type and concentration of superdisintegrant used. Sodium starch glycolate exhibited the highest swelling capacity, croscarmellose sodium provided rapid water penetration and disintegration, while cros povidone showed comparatively lower swelling behaviour.
subject: Articles
  topic: section
subject: Theophylline
  topic: keywords
subject: Pellets
  topic: keywords
subject: Extrusion-spheronization
  topic: keywords
subject: superdisintegrants
  topic: keywords
subject: Drug release
  topic: keywords
subject: Dissolution studies
  topic: keywords
subject: croscarmellose sodium
  topic: keywords
subject: sodium starch glycolate
  topic: keywords
creator: Kakarla Charan Kumar Reddy
creator: U. Supriya
creator: G. Srinivasa Rao
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-06-30
publication date: 2026-06-30
starting page: 49
ending page: 53
doi: 10.30904/j.jpbr.2026.4987

Evaluation and Characterization of Losartan and Hydrochlorothiazide fixed dose as Gastroretentive bilayered floating tablets
type: item
description: Losartan potassium (LSP) is a potent, highly specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity. It is readily absorbed from the gastrointestinal tract with oral bioavailability of about 33% and a plasma elimination half-life ranging from 1.5 to 2.5. Hydrochlorothiazide is a thiazide diuretic and is used in the treatment of mild to moderate hypertension. It is very slightly soluble in water having plasma half life of 6h to 14h. Therefore an attempt was made to increase oral bioavailability of Losartan and Hydrochlorothiazide fixed dose combination by retaining the dosage form in stomach for longer period of time. This is achieved by developing gastroretentive floating drug delivery system. These tablets were prepared to increase the bioavailability of the drugs by utilizing the drugs to full extent avoiding unnecessary frequency of dosing and subsequently first pass metabolism.
subject: Articles
  topic: section
subject: Losartan
  topic: keywords
subject: Optimization
  topic: keywords
subject: Hydrochlorothiazide
  topic: keywords
subject: fixed dosa
  topic: keywords
subject: gastroretentive
  topic: keywords
subject: bilayered floating tablets
  topic: keywords
subject: antagonist
  topic: keywords
subject: LSP
  topic: keywords
creator: Yasoda Krishna Kottala
creator: Priyadarsini M
rights: Copyright (c) 2021 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2021-10-24
publication date: 2021-10-24
starting page: 28
ending page: 32
doi: 10.30904/j.jpbr.2021.4519

Stability Studies of Optimized Formulation of Losartan and Hydrochlorothiazide Bilayer Floating Tablets
type: item
description: The prasent study was to develop an optimal gastroretentive drug delivery system for administering Losartan and Hydrochlorothiazide as a fixed dose combination for antihypertensive therapy. The bilayer tablets were prepared by direct compression method. Losartan potassium and Hydrochlorothiazide were formulated and optimized separately as a floating and immediate release layer. Losartan was formulated as a floating layer using hydrophillic swellable polymer HPMC K4M, ethyl cellulose (4cps) as a bouyancy enhancer and sodium bicarbonate as a gas generating agent. The amount of polymer blends was optimized using 23 full factorial design. The influence of experimental factors such as swelling agent concentration, buoyancy enhancer and gas generating agent on floating lag time, total floating time, T 50% and % drug release were investigated to get optimized formulation. The responses were analyzed using ANOVA and polynomial equation was generated for each response using MLRA. All formulations floated for more than 12 hours. The study revealed that the optimized bilayer floating tablet retains in rabbit stomach for 9 h. The optimized formulation was subjected to stability study for three months at 400C /75% RH. The stability study showed no significant change in appearance of tablets, floating characteristics, drug content and in- vitro drug dissolution.
subject: Articles
  topic: section
subject: Bi-layer floating tablets
  topic: keywords
subject: Optimization
  topic: keywords
subject: ANOVA
  topic: keywords
subject: uperdisintegrants
  topic: keywords
subject: elease-retarding polymer
  topic: keywords
subject: in vivo x ray imaging study
  topic: keywords
creator: Yasoda Krishna Kottala
creator: Priyadarsini M
rights: Copyright (c) 2022 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2022-11-04
publication date: 2022-11-04
starting page: 42
ending page: 48
doi: 10.30904/j.jpbr.2022.4559

Study of Effect of Various Polymers in the Formulation Development of Mucoadhesive Buccal Tablets of Propranolol HCL
type: item
description: The release rate of Propranolol HCl from buccal tablets was found to be influenced primarily by the type and concentration of polymer used in tablet formulation. The controlled drug release following first-order kinetics demonstrated that hydrophilic matrix tablets prepared with Carbopol 934 and HPMC K100 are effective as buccoadhesive controlled-release delivery systems. Both pre-compression and post-compression evaluation parameters for all formulations were within acceptable limits. The matrix tablets formulated with HPMC K100 (Formulation F5) exhibited slow, controlled, and nearly complete drug release over 11 hours, achieving 93.45% drug release. These findings suggest that the selected polymers successfully regulate the release profile of Propranolol HCl in buccal delivery systems, ensuring sustained therapeutic effects.
subject: Articles
  topic: section
subject: Propranolol HCl
  topic: keywords
subject: buccal tablets
  topic: keywords
subject: controlled release
  topic: keywords
subject: hydrophilic matrix
  topic: keywords
subject: Carbopol 934
  topic: keywords
subject: HPMC K100
  topic: keywords
creator: Anuhya Adimulam
creator: Nagasree K
creator: Laxmi P
creator: Shravan Kumar K
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-05-14
publication date: 2026-05-14
starting page: 44
ending page: 48
doi: 10.30904/j.jpbr.2026.4986

Design and Characterization of Lansoprazole Delayed Release Tables Employing Novel Entric Coating Agents
type: item
description: The present study aimed to enhance the solubility and dissolution rate of Lansoprazole through the preparation of solid dispersions using Hydroxypropyl-β-cyclodextrin (HP-β CD) and to further develop sustained release formulations. Solid dispersions of Lansoprazole were prepared by three different methods physical mixture, kneading method, and co precipitation method in varying drug-to-carrier ratios (1:1 and 1:2). Among these, the co-precipitation method demonstrated the highest enhancement in solubility, followed by the kneading method and the physical mixture, indicating the order: Physical mixture < Kneading method < Co-precipitate method. The optimized formulation (CP-2: Drug: HP β-CD at 1:2 ratio by co-precipitation method) exhibited superior solubility enhancement and dissolution performance. Lansoprazole–HP-β-cyclodextrin complexes showed a significantly higher dissolution rate and efficiency compared to pure Lansoprazole and its conventional capsule forms. These optimized solid dispersions were further utilized to formulate sustained release tablets using different grades of HPMC (K4M, K15M, and K100M) as release-retarding polymers. The pre-compression parameters, including angle of repose, bulk density, tapped density, and compressibility index, indicated excellent flow properties suitable for direct compression. Drug release studies revealed that an increase in polymer concentration led to a reduction in the drug release rate, with formulation F8 exhibiting the most desirable sustained release profile. Kinetic modeling confirmed that the drug release followed zero-order kinetics and obeyed the Higuchi diffusion model, indicating a diffusion-controlled release mechanism.
subject: Articles
  topic: section
subject: Lansoprazole
  topic: keywords
subject: solid dispersions
  topic: keywords
subject: Hydroxypropyl-β-cyclodextrin (HP-β-CD)
  topic: keywords
subject: co-precipitation method
  topic: keywords
subject: dissolution rate
  topic: keywords
creator: Sneha Sollu
creator: Nagasree K
creator: Laxmi P
creator: Shravan Kumar K
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-05-14
publication date: 2026-05-14
starting page: 39
ending page: 43
doi: 10.30904/j.jpbr.2026.4984

Artificial Intelligence in Pharmaceutical Regulatory Compliance: Data Integrity, AI Validation, and Digital QA Systems
type: item
description: Artificial Intelligence (AI) is increasingly transforming pharmaceutical industries by enhancing data integrity, audit trail compliance, electronic documentation, AI validation, and digital quality assurance systems. Modern pharmaceutical manufacturing and analytical laboratories generate large volumes of digital data that require secure management, accurate documentation, and continuous regulatory compliance. Conventional manual quality systems are often time-consuming, error-prone, and difficult to manage efficiently in highly regulated environments. The integration of AI technologies into pharmaceutical quality and compliance systems enables intelligent automation, predictive monitoring, and real-time decision-making.AI-driven systems improve data integrity by identifying inconsistencies, detecting abnormal data patterns, and minimizing the risk of unauthorized data manipulation. Advanced machine learning algorithms support automated audit trail review, anomaly detection, and risk-based compliance monitoring. AI-assisted electronic documentation systems enhance data accuracy, reduce manual transcription errors, and improve workflow efficiency through automated report generation and intelligent document management.AI validation has become essential to ensure the reliability, reproducibility, and regulatory acceptance of machine learning models used in pharmaceutical operations. Additionally, AI-integrated digital quality assurance systems support predictive quality monitoring, deviation management, CAPA activities, and real-time process control. These technologies improve operational efficiency, strengthen regulatory compliance, and enhance product quality. This review highlights the applications, benefits, challenges, and future perspectives of AI integration in pharmaceutical data integrity and digital quality management systems.
subject: Articles
  topic: section
subject: Artificial Intelligence
  topic: keywords
subject: Data Integrity
  topic: keywords
subject: Audit Trail Compliance
  topic: keywords
subject: Digital Quality Assurance
  topic: keywords
subject: Pharmaceutical Industries
  topic: keywords
creator: Jai Surya I
creator: Brindha Shree V
creator: Abdul Basith J
creator: Balagopal J
creator: Dharshini P
creator: Ravisankar Mathesan
creator: Nataraj Palaniyappan
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-05-14
publication date: 2026-05-14
starting page: 34
ending page: 38
doi: 10.30904/j.jpbr.2026.4983

Development and Evaluation of Fast Dissolving Tablets of Pravastatin by Enhancing Dissolution Rate and Bioavailability
type: item
description: Pravastatin orally disintegrating films were successfully formulated using HPMC E15CPS and combinations of HPMC E15 and HPMC E5 polymers. Visual inspection and tactile evaluation revealed that the films possessed a smooth surface and were visually appealing. The film thickness ranged between 0.234 mm and 0.271 mm, with weight variation within ±10%. Folding endurance values ranged from 38 ± 1 to 57 ± 2, indicating good flexibility. Surface pH measurements showed neutrality with no color change on litmus paper, ensuring suitability for oral administration. Drug content uniformity tests demonstrated consistent drug loading, ranging from 98% to 102%. The films exhibited rapid disintegration times between 21 and 32 seconds. Among all batches, formulation F-9 displayed optimal mechanical properties and an in vitro disintegration time under 27 seconds, making it the most suitable formulation. Overall, formulation F-9 met the desired criteria and was selected as the optimized batch for further evaluation. This study confirms the potential of these orally disintegrating films as effective delivery systems for Pravastatin, combining acceptable mechanical strength, uniform drug distribution, and rapid disintegration for enhanced patient compliance.
subject: Articles
  topic: section
subject: HPMC E15
  topic: keywords
subject: HPMC E5
  topic: keywords
subject: rapid disintegration
  topic: keywords
subject: mechanical properties
  topic: keywords
subject: drug content uniformity
  topic: keywords
subject: film thickness
  topic: keywords
creator: Sowjanya Golanukonda
creator: Nagasree K
creator: Laxmi P
creator: Shravan Kumar K
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-05-14
publication date: 2026-05-14
starting page: 29
ending page: 33
doi: 10.30904/j.jpbr.2026.4982

Assay Technologies in Pharmaceutical and Biomedical Sciences: Principles, Classification, Validation, and Emerging Innovations
type: item
description: Assay technologies constitute fundamental analytical tools for the detection, identification, and quantification of chemical, biological, and molecular entities across pharmaceutical, clinical, environmental, and research domains. Rapid advancements in instrumentation, automation, miniaturization, and data analytics have significantly improved assay sensitivity, specificity, throughput, and reproducibility. This research-oriented review systematically evaluates the classification, working principles, operational mechanisms, validation parameters, applications, advantages, and limitations of major assay technologies, including chemical, biological, immunological, chromatographic, spectroscopic, electrochemical, and molecular assays. Furthermore, recent technological innovations such as lab-on-a-chip platforms, point-of-care diagnostics, multiplex assays, biosensors, next-generation sequencing, and artificial intelligence–assisted interpretation are critically discussed. The study aims to provide a structured and comprehensive scientific overview of assay methodologies for pharmacy professionals and researchers, emphasizing regulatory compliance and quality assurance frameworks.
subject: Articles
  topic: section
subject: Assay technologies
  topic: keywords
subject: Bioassay
  topic: keywords
subject: Immunoassay
  topic: keywords
subject: Chromatography
  topic: keywords
subject: Molecular diagnostics
  topic: keywords
subject: Validation
  topic: keywords
subject: Pharmaceutical analysis
  topic: keywords
subject: Biosensors
  topic: keywords
creator: Salma Sultana SK
creator: Lalitha CH
creator: Venkata Harsha Vardan D
creator: Likitha P
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-05-14
publication date: 2026-05-14
starting page: 25
ending page: 28
doi: 10.30904/j.jpbr.2026.4945

Formulation and Evaluation of Polyherbal Dosage Form Exhibiting Anti Acne Activity
type: item
description: The present study was undertaken to develop and evaluate a polyherbal topical gel formulation containing Opuntia ficus-indica, Piper nigrum, and Pterocarpus santalinus for the management of acne vulgaris. Acne is a chronic inflammatory disorder of the pilosebaceous unit associated with microbial infection, excessive sebum production, and oxidative stress. Herbal medicines, rich in bioactive phytoconstituents, provide a safer and effective alternative to conventional therapies. In this study, selected plant materials were subjected to pharmacognostic evaluation, extraction, and phytochemical screening. The extracts were further evaluated for antibacterial activity against acne-causing microorganisms. The polyherbal gel was formulated using suitable gelling agents and evaluated for physicochemical parameters, stability, and efficacy. The results demonstrated significant antimicrobial activity, especially in alcoholic extracts, along with the presence of flavonoids, tannins, alkaloids, and phenolic compounds. The formulated gel showed good consistency, stability, and therapeutic potential. The study concludes that the developed polyherbal gel is a promising natural alternative for acne treatment with improved safety and efficacy.
subject: Articles
  topic: section
subject: Polyherbal gel
  topic: keywords
subject: Acne vulgaris
  topic: keywords
subject: Antimicrobial activity
  topic: keywords
subject: Opuntia ficus-indica
  topic: keywords
subject: Piper nigrum
  topic: keywords
subject: Pterocarpus santalinus
  topic: keywords
subject: Herbal formulation
  topic: keywords
creator: Muni Sekhar Vonteru
creator: Swapna M
creator: Purusothamakumar K
creator: Aravind A
creator: Jyothika K
creator: Pavan T
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-04-04
publication date: 2026-04-04
starting page: 21
ending page: 24
doi: 10.30904//j.jpbr.2026.4956

Bacterial Biofilm Formation on Infant Pacifiers and Its Impact on Feeding Habits: Evaluation of the Antimicrobial Activity of Selected Plant Extracts
type: item
description: Pacifiers are widely used as soothing devices for infants, but their frequent exposure to saliva and environmental contaminants makes them potential reservoirs for microbial colonization. The present study aimed to investigate bacterial contamination and biofilm formation on infant pacifiers and to evaluate the antimicrobial activity of selected plant extracts. Pacifiers were collected from infants aged 6 months to 2 years, and bacterial isolates were identified using morphological and biochemical methods. The antimicrobial activity of Prosopis juliflora and Allium cepa extracts was tested using the agar well diffusion method. Results revealed significant bacterial contamination, including Staphylococcus spp., Streptococcus spp., Escherichia coli, Klebsiella spp., Pseudomonas spp., and Bacillus spp. The plant extracts showed dose-dependent antibacterial activity. The findings highlight the importance of proper hygiene practices and suggest that plant-based antimicrobials can be effective alternatives for controlling microbial contamination on pacifiers.
subject: Articles
  topic: section
subject: Pacifiers
  topic: keywords
subject: Biofilm
  topic: keywords
subject: Infant health
  topic: keywords
subject: Prosopis juliflora
  topic: keywords
subject: Allium cepa
  topic: keywords
subject: Antimicrobial activity
  topic: keywords
creator: Shafrina Jahan S
creator: Kaviya R
creator: Tamizhazhagan V
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-03-23
publication date: 2026-03-23
starting page: 17
ending page: 20
doi: 10.30904/10.30904/j.jpbr.2026.4938

Preparation and Evaluation of Herbal Cream Formulated from Calotropis gigantea Leaves
type: item
description: The present study aimed to formulate and evaluate a topical herbal cream using the leaf extract of Calotropis gigantea. Medicinal plants serve as an important source of bioactive compounds with significant therapeutic potential. Calotropis gigantea, widely used in traditional medicine, possesses antimicrobial, anti-inflammatory, and wound-healing properties. Fresh leaves were collected, authenticated, shade dried, pulverized, and subjected to Maceration extraction using propylene glycol. Preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, tannins, glycosides, saponins, and terpenoids. An oil-in-water (O/W) emulsion-based cream was formulated using suitable excipients. Four trial formulations (F1C–F4C) were prepared and evaluated for physicochemical properties including organoleptic characteristics, pH, spreadability, washability, phase separation, and skin irritation. The prepared formulations showed smooth texture, faint yellow color, pleasant odor, and semi-solid consistency. No irritation, erythema, edema, or phase separation was observed. Spreadability values indicated good applicability. The optimized formulation exhibited acceptable pH suitable for skin application. The study confirms the feasibility of developing a stable and safe herbal topical preparation using Calotropis gigantea leaf extract with potential therapeutic applications.
subject: Articles
  topic: section
subject: Calotropis gigantea
  topic: keywords
subject: Herbal cream
  topic: keywords
subject: Oil-in-water emulsion
  topic: keywords
subject: Phytochemical screening
  topic: keywords
subject: Spreadability
  topic: keywords
subject: Topical formulation
  topic: keywords
subject: Wound healing
  topic: keywords
subject: Anti-microbial activity
  topic: keywords
creator: Revathi Sarvepalli
creator: Divya Battala
creator: Vardhan Ediga
creator: Charunya K
creator: Sai Manu Katta
creator: Varalakshmi Kunda
creator: Ramesh Y
creator: Prapurna Chandra Y
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-03-21
publication date: 2026-03-21
starting page: 13
ending page: 16
doi: 10.30904/j.jpbr.2026.4937

A Review on Ebola Virus Disease and Its Prevention and Management in Community
type: item
description: Ebola virus disease is a devastating hemorrhagic disease that is often fatal, has been plaguing Africa since its initial discovery in 1976. For more than 42 years, the disease has claimed the lives of over 15,000 people, with no significant changes in case fatality rates. However, as the global response to EVD evolves, we continue to learn about better ways to diagnose, treat and prevent this disease. EVD does not naturally occur in the human population; it is introduced after exposure to close contact with the secretions, meat or bodily fluids of animals, such as fruit bats, monkeys or other rainforest animals. The World Health Organization states that 2 negative RT-PCR test results, at least 48 hours apart, are required for a clinically asymptomatic patient to be discharged from hospital. Destruction of other tissue cells results in myalgias from myositis, hepatitis, and acute kidney injury from renal tubular dysfunction. Immune-mediated cell damage causes further injury, leading to dysfunction in multiple vital organs such as the lungs, heart, kidney, and liver. More healthcare programmes are required to conducting a large scale for developing the awareness about Ebola virus disease about preventive measures and eradication process. Extensive research investigations are needed to developed in an accurate diagnostic procedure as well as an affordable and rapid treatment initiatives can control Ebola virus infection.
subject: Articles
  topic: section
subject: Ebola virus disease
  topic: keywords
subject: World health organization
  topic: keywords
subject: Vital organs
  topic: keywords
subject: Research investigations
  topic: keywords
subject: Treatment initiatives.
  topic: keywords
creator: Vidhyadhari Arava
creator: Kalyan Erri
creator: Jaswanth Gottiganti
creator: Ravi Kumar Konduru
creator: Arun S
creator: Narasimhulu Salivindula
creator: Nandabaskar Kommeri
creator: Sudharani Chinta
creator: Haritha Mogali
creator: Rajini Sura
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-03-15
publication date: 2026-03-15
starting page: 09
ending page: 12
doi: 10.30904/

Plant-Based Multifunctional Nutraceuticals as Preventive Interventions for Modern Lifestyle Disorders
type: item
description: In recent years, herbal formulations and nutraceuticals have gained wide acceptance due to their minimal adverse effects. Medicinal plants are known for their immune-enhancing properties, and nutrition during early childhood plays a crucial role in a child’s overall growth and development. Despite consuming a balanced diet, children often suffer from deficiency-related disorders. Owing to their close interaction with gut microbiota, nutraceuticals currently serve as an effective alternative for the prevention and management of dysfunctions associated with oxidative stress. Chronic non-communicable diseases such as cancer, diabetes, hormonal disorders including PCOS, cardiovascular diseases, neurodegenerative conditions, and autoimmune disorders are increasing worldwide, creating significant health and economic burdens. The primary objective of this study was to develop a multifunctional nutraceutical formulation using ingredients derived from various sources such as medicinal herbs, seeds, spices, and green leafy vegetables. The pharmacological efficacy of the formulation was evaluated through its mechanisms of action, including biotransformation processes and identification of relevant biomarkers. Since inflammation is one of the major contributing factors to disease progression, its reduction is essential, as it promotes the generation of free radicals and gut dysbiosis.
subject: Articles
  topic: section
subject: Nutraceutical
  topic: keywords
subject: non-communicable diseases
  topic: keywords
subject: biomarkers
  topic: keywords
subject: free radicals
  topic: keywords
subject: dybiosis
  topic: keywords
creator: Usha Kiran Reddy T
creator: Gunasree K
creator: Sreevalli G.V.N
creator: Umar Farooq S.K
creator: Uma Maheswari T
rights: Copyright (c) 2026 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-03-10
publication date: 2026-03-10
starting page: 01
ending page: 08
doi: 10.30904/j.jpbr.2026.4920

Investigation of Antidiabetic Activity and Antioxidant Activity of Moringa Oleifera in Rats
type: item
description: Plants have been used as source of drugs for the treatment of diabetes mellitus in developing countries where the cost of conventional medicines represents a burden to the population. Many species have been reported to present antidiabetic activity. Moringa oleifera is a plant traditionally used for the treatment of diabetes mellitus. This dissertation was designed based in the traditional claim to emphasize the antihyperglycemic, antioxidant potential of the ethanolic extract of Moringa oleifera. Preliminary phytochemical analysis of the EEMO extract of leaf of the plant showed that the plant has a rich possession of phytochemicals like flavonoids and steroids. In the sub-acute study, a steady decrease in blood glucose level was observed on EEMO treatment in Alloxan induced diabetic rats. The treatment of EEMO showed marked increase in body weight, marked increase in protein, HDL cholesterol levels in serum of Alloxan induced diabetic animals. EEMO has high scavenging activity against DPPH free radical generating system so it is considered to be a anti-oxidant. Based on the obtained results and observations, we can infer that the Moringa oleifera could be used for the supportive treatment of diabetes mellitus, as the plant also offers effective protection against free radicals that form the basis for the development of diabetic complications.
subject: Articles
  topic: section
subject: Moringa oleifera
  topic: keywords
subject: Antidiabetic activity
  topic: keywords
subject: Anti-oxidant activity
  topic: keywords
creator: Madhuri Ramoju
creator: Nagaraju Nagaraju
creator: Kulkarni M
creator: Murali Sollu
creator: Vijay Kumar Gampa
rights: Copyright (c) 2020 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2020-10-27
publication date: 2020-10-27
starting page: 24
ending page: 34
doi: 10.30904/j.jpbr.2020.4289

Analytical Method Development and Validation of Chloro Impurity and Methyl Ester Impurity by Using RP-HPLC
type: item
description: A simple and precise RP-HPLC method was developed for the determination of Apixaban impurities like Chloro impurity and Methyl ester impurity. The chromatographic separation was achieved on an Zorbax Bonus RP (250 X 4.6mm) column with a mobile phase contain the gradient mixture of the solvents (Acetonitrile: water) in the ratio of 90:10(v/v). The eluted compounds were monitored at 270nm and the run time was 35mints.The method is repeatable and can be used for routine analysis of Apixaban in bulk and in pharmaceutical formulation. Hence it is more effective, sensitive and the impurities profile can be analyzed easily through this method. The development and validated RP-HPLC method is applied for identification of eluted the impurities.
subject: Articles
  topic: section
subject: RP-HPLC
  topic: keywords
subject: Method Validation
  topic: keywords
subject: Chloro impurity
  topic: keywords
subject: Methyl ester impurity
  topic: keywords
creator: Suryanarayana Gottapu
creator: Satyaveer Singh
rights: Copyright (c) 2020 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2020-06-27
publication date: 2020-06-27
starting page: 19
ending page: 23
doi: 10.30904/j.jpbr.2020.4288

Therapeutic strategies on Blood brain barrier
type: item
description: BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. It is a vital component of the neurovascular unit (NVU) containing tight junctional (TJ) proteins and different ion and nutrient transporters which maintain normal brain physiology. The blood-brain barrier (BBB) is responsible for much of this difficulty but also provides an essential separation from systemic circulation. Due to the BBB’s physical and chemical constraints, many current therapies, from cytotoxic drugs to antibody-based proteins, cannot gain access to the tumor. Various strategies are being developed to enhance the amount and concentration of therapeutic compounds in the brain. The present review describes those different approaches of therapeutic strategies on blood brain barrier. These approaches are mainly utilized to overcome the brain tumors.
subject: Articles
  topic: section
subject: Blood brain barrier (BBB)
  topic: keywords
subject: Neurovascular unit
  topic: keywords
subject: Brain
  topic: keywords
subject: Therapy
  topic: keywords
subject: Systemic circulation
  topic: keywords
creator: Surendra K
creator: Yasoda K
creator: Govardhini G
creator: Soundarya M
creator: Sowjanya P
rights: Copyright (c) 2020 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2020-06-27
publication date: 2020-06-27
starting page: 14
ending page: 18
doi: 10.30904/j.jpbr.2020.4287

Investigation of Anti-Ulcer Activity of Triticum Aestivum in Rats
type: item
description: My present aim was to investigate the anti-ulcer activity of Triticumaestivum in rats. Triticumaestivum is rich in phytoconstituents such as Alkaloids, flavonoids, tannins and phenolic compounds, Carbohydrates, glycosides and steroids. Peptic ulcers are the wounds or lesions caused on the linings of either stomach or intestine. Aspirin (200 mg/kg) was administered to rats for 3 days to induce ulcers by reducing prostaglandin synthesis. Ranitidine (20mg/kg) was used as standard drug. Test doses of ethanolic extract of Triticumaestivum (EETA) 100mg/kg, 200mg/kg were administered to rats. Standard drug and test doses of EETA were administered 30 minutes before aspirin administration and after 24 hours the rats are anaesthetized, dissected and stomach mucosal layer and gastric juice were collected and evaluated for free acidity, total acidity, ulcer index, gastric volume and PH. It was observed that Test dose of EETA, 200mg/kg had shown significant decrease in all above mentioned parameters.
subject: Articles
  topic: section
subject: Triticumaestivum
  topic: keywords
subject: Aspirin
  topic: keywords
subject: Prostaglandins
  topic: keywords
subject: Ranitidine
  topic: keywords
subject: Flavonoids
  topic: keywords
subject: Glycosides
  topic: keywords
creator: Deepika K
creator: Sridhar Y
creator: Murali Sollu
creator: Vijay Kumar Gampa
rights: Copyright (c) 2020 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2020-06-27
publication date: 2020-06-27
starting page: 09
ending page: 13
doi: 10.30904/j.jpbr.2020.4286

Current Appraisal Procedures for New Regulations, Standards, Policies, and Guidance Issued by Regulatory Authorities
type: item
description: Regulatory Affairs Profession believe the new approach to regulation will eventually be adopted for all healthcare products as it represents the best model for delivering new healthcare advances to market in a reasonable time with acceptable safety. Most companies, whether they are major multinational pharmaceutical corporations or small, innovative biotechnology companies, have specialist departments of Regulatory affairs professionals and Regulatory affairs department is constantly evolving the one which is least impacted during the acquisition and merger, and also during recession. Due to the changing resources necessary to fulfill the regulatory requirements, some companies also choose to outsource or out task regulatory affairs to external service providers. In today’s competitive environment the reduction of the time taken to reach the market is critical to a product’s and hence within the company’s for their success and growth. The proper conduct of its Regulatory Affairs activities is therefore of considerable economic importance for the company.
subject: Articles
  topic: section
subject: Regulatory affairs
  topic: keywords
subject: Health care products
  topic: keywords
subject: Economic
  topic: keywords
subject: Pharmaceutical Corporations
  topic: keywords
creator: Sree Lakshmi Kumari
creator: Sunil kumar K
rights: Copyright (c) 2020 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2020-06-27
publication date: 2020-06-27
starting page: 01
ending page: 08
doi: 10.30904/j.jpbr.2020.4284

Analytical Method Development and Validation for the Simultaneous Estimation of Gabapentin and Nortriptyline by RP-HPLC method
type: item
description: In RP-HPLC method, the conditions were optimized to obtain an adequate separation of eluted compounds. Initially, various mobile phase compositions were tried, to separate title ingredients. Mobile phase and flow rate selection was based on peak parameters (height, tailing, theoretical plates, capacity or symmetry factor), run time and resolution. The mobile phase containing mixture of Phophate buffer solution: Methanol (65:35v/v, pH 4) with a flow rate of 1.0 ml/min is quite robust. The optimum wavelength for detection was 260 nm at which better detector response for both the drugs was obtained. The retention times for Gabapentin and Nortriptyline was found to be 2.113 min and 3.560 min, respectively. To ascertain its effectiveness, system suitability tests were carried out on freshly prepared stock solutions. The calibration was linear in concentration range of 5 to 25μg/ ml and 20 to 100μg/ml, with regression 0.9979 and 0.9999, Gabapentin and Nortriptyline respectively. The low values of % R.S.D indicate the method is precise and accurate. The mean recoveries were found above 99.3 % for both the drugs.
subject: Articles
  topic: section
subject: Gabapentin
  topic: keywords
subject: Nortriptyline
  topic: keywords
subject: RP-HPLC
  topic: keywords
subject: Validation
  topic: keywords
creator: Subahani Sk
creator: Hari Baskar V
rights: Copyright (c) 2021 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2021-10-21
publication date: 2021-10-21
starting page: 22
ending page: 27
doi: 10.30904/j.jpbr.2021.4509

Design, Development and Validation of Bioanalytical Methods for Pharmaceutical Formulations – Review
type: item
description: Any method developed for the analysis of analytes in biological fluids must yield consistent results despite the variations in conditions during the course of a project. An ideal bioanalytical method should include all of the probable effects that are going to occur during the routine analysis of study samples. Bioanalytical method validation includes all of the procedures that demonstrate that a particular method used for quantitative measurement of analytes in a given biological matrix, such as blood, plasma, serum, or urine is reliable and reproducible for the intended use. Method development for the interested drug/analyte in finished product or in process tests and the sample preparation of drug product and to provide practical approaches for determining selectivity, specificity, limit of detection, limit of quantitation, linearity, range accuracy, precision, recovery solution stability, ruggedness, and robustness of liquid chromatographic methods to support the Routine, in process and stability analysis. The present review aims to study the bioanalytical method development and validation for various pharmaceutical formulations.
subject: Articles
  topic: section
subject: Bioanalytical
  topic: keywords
subject: Method development
  topic: keywords
subject: Validation
  topic: keywords
creator: Subramanian R
creator: Purushothaman M
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 102
ending page: 108
doi: 10.30904/j.jpbr.2016.3398

A Review on Satellite DNA
type: item
description: Satellite DNAs are hidden part of the genomes, initially just considered as junk DNA. Heterochromatic regions of the eukaryotic genome harbour DNA sequences that are repeated many times in tandem, collectively known as satellite DNAs. Different satellite sequences co‐exist in the genome, thus forming a set called a satellite DNA library. Satellite DNA families accumulate in the in the heterochromatin in different parts of the eukaryotic chromosomes, mainly in pericentromeric and subtelomeric regions, there is currently an increasing appreciation of the functional significance of satellite DNA repeats and of their sequences. The study of insect satellite DNAs indicates the evolutionary conservation of certain features despite their sequence heterogeneity. Such features can include total length, monomer length, motifs, particular regions and/or secondary and tertiary structures.
subject: Articles
  topic: section
subject: satellite DNA
  topic: keywords
subject: minisatellite
  topic: keywords
subject: microsatellite
  topic: keywords
subject: centromere
  topic: keywords
creator: Mounika A
creator: Gowramma A
creator: Susanna E
creator: Prathibha B
creator: Rathna kala P
creator: Siva kumari P
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 99
ending page: 101
doi: 10.30904/j.jpbr.2016.3188

Art Therapy: A Scientific Review
type: item
description: Art therapy is a creative method of expression used as a therapeutic technique. Art therapy originated in the field of art and psychotherapy and may varying definition. The British artist Adrianhillcoined the termed art therapy in 1942 award Adamson the father of art therapy in Britain art therapy and outside art. Paediatric trauma patient’simpartment of depression and locus of controlling prison in mates. The porpoise of art therapy is essentially one of heeling general illness, cancer, diagnosis, bereaved children and in carceviton. Dyslexia is a widely held opinion that dyslexia associated with remarkably artistic creativity.
subject: Articles
  topic: section
subject: art therapy
  topic: keywords
subject: trauma
  topic: keywords
subject: dyslexia
  topic: keywords
subject: depression
  topic: keywords
subject: paediatrics
  topic: keywords
subject: bereaved children
  topic: keywords
creator: Venkata Ramana M
creator: Leela Lakshmi V
creator: Venkatesh P
creator: Madhavi Latha C
creator: Sravani B
creator: Rama T
creator: Sravanthi G
creator: Naveen G
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 95
ending page: 08
doi: 10.30904/j.jpbr.2016.3180

Water cure Therapy: A Review
type: item
description: This water therapy, also known as Indian, Chinese, or Japanese water Therapy, is claimed to have a wide range of health benefits, or at least no adverse effects. Advocates of water therapy claim that application of water therapy at first will cause multiple bowel movements until the body adjusts to the increased amount of fluid. Without spending money and medicine, tablet, injections, diagnosis, doctor fees etc. Just by drinking –pure water you will find that many diseases can be cured lick hyper tension, anaemia, obesity etc... One from water therapy, advocated by some alternative medicine proponents, is the consumption of a gutful of water upon waking in order cleans the bowel. A litter to a litter- a- half is the common amount ingested. This water therapy also known as Indian, chaines, and japans water therapy is claimer to have a wide range of health benefits or at least no adverse effects.
subject: Articles
  topic: section
subject: water
  topic: keywords
subject: blood pressure
  topic: keywords
subject: enzymes
  topic: keywords
subject: reabsoption
  topic: keywords
subject: absorption
  topic: keywords
creator: Naveen G
creator: Leela Lakshmi V
creator: Venkatesh P
creator: Madhavi Latha C
creator: Sravani B
creator: Rama T
creator: Venkata Ramana M
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 91
ending page: 94
doi: 10.30904/j.jpbr.2016.3176

Effect of Hydroalcoholic Extract of Orthosiphon Thymiflorus Leaves on Glycemia of Diabetic Rats
type: item
description: The present study was aimed to investigate the antihyperglcemic activity of hydroalcoholic extract of Orthosiphon thymiflorus leaves (HAEOT) on high fat diet (HFD) - streptozotocin (STZ) induced diabetic rats. Male wistar albino rats were fed with a high fat diet for a period of two weeks prior to the administration of streptozotocin (50mg/kg) intraperitonially. The long term effect of the extract was studied by treating diabetic rats with vehicle (0.5% CMC) and HAEOT (200 and 400 mg/kg b wt) for a period of 28 days. The effects of HAEOT on fasting blood glucose and serum insulin levels were studied. In addition, body weight changes, lipid profile and serum biomarkers of liver and kidney function were also studied. Results revealed that HAEOT-400mg shows excellent anti hyperglycemic activity when compared to lower dose of the extract 200mg and also shows better anti hyperlipidemic activity. The elevated serum urea and creatinine levels also decreased by the treatment with extract. Hence the results justify that Orthosiphon thymiflorus possess antidiabetic activity.
subject: Articles
  topic: section
subject: Orthosiphon thymiflorus
  topic: keywords
subject: Anti-diabetic activity
  topic: keywords
subject: Streptozotocin
  topic: keywords
creator: Riyazunnisa D
creator: Ali Sultan
creator: Karimulla Shaik
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 86
ending page: 90
doi: 10.30904/j.jpbr.2016.3368

Formulation of Mucoadhesive Microspheres of Irbesartan and Their Evaluation
type: item
description: Mucoadhesive microspheres has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption thereby improving and enhancing the bioavailability of drugs. Irbesartan is an Angiotensin receptor blocker (ARB) used mainly for the treatment of hypertension. It competes with Angiotensin II for binding at the AT1 receptor sub type. The mucoadhesive microspheres of Irbesartan were formulated by orifice ionic gelation technique employing polymers like Sodium Carboxy methyl cellulose and Carbopol along with Sodium alginate. The microspheres prepared were discrete, spherical and free flowing. Microspheres were evaluated for particle size, percentage yield, flow properties, drug content, and drug entrapment efficiency, percentage moisture loss, swelling property, in vitro drug release, drug release kinetics, in vitro wash-off test, stability study and drug polymer interaction study by FT-IR. The microencapsulation efficiency was found relatively high with 2% polymer. Average particle size was found in the range of 5.02±0.36 to 9.45±0.43μm. Formulations F6 displayed the best results for. Entrapment efficiency was 85.26±0.43%, swelling-index was 194±3.45% and drug release up to 8h was 94.97%. Drug release was diffusion controlled and followed first order kinetics. The in vitro wash-off test indicated that the microspheres had good mucoadhesive properties. Hence prepared mucoadhesive microspheres may be an effective strategy for the development of easy, reproducible and cost effective method for safe and effective oral drug therapy.
subject: Articles
  topic: section
subject: Irbesartan
  topic: keywords
subject: Angiotensin
  topic: keywords
subject: Mucoadhesive Microspheres
  topic: keywords
creator: Jayshri A. Patil
creator: Harshal S. Bhandari Harshal S. Bhandari
creator: Tanvirahmad J. Shaikh Tanvirahmad J. Shaikh
creator: Trupti C. Mahajan Trupti C. Mahajan
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2026-01-12
publication date: 2026-01-12
starting page: 78
ending page: 85
doi: 10.30904/j.jpbr.2016.3282

A study on traditional medicinal plants of Pillur Beat (Pillur slope RF and Nellithurai RF), Karamadai range, Coimbatore district, Tamil Nadu.
type: item
description: Objective: To explore traditional ethnomedicinal knowledge of Irula tribes of Pillur Beat (Pillur slope RF and Nellithurai RF), Karamadai Range, Western Ghats, Tamil Nadu, India. Methods: With the help of semi-structure questionnaire, resource persons were interviewed on medicinal use of local flora in six tribal villages of Pillur Beat, during the months of Jan 2016 to Aug 2016 with frequent field visits in the study area. Results: A total of 80 plant species belonging to 73 genera of 41 families were reported in the study area, of which trees ranked first with 36 species. In terms of the number of medicinal plant species in a family, Euphorbiaceae (8 species) is the dominant family. Leaves were most frequently used plant part for the treatment of diseases. Decoction ranks first in the mode of administration. Conclusion: Our study revealed that in all the studied tribal villages the plants were used to cure common diseases like fever, skin diseases, wound healing, asthma, etc. Many of these plants in the study area are to be conserved. The study also suggested that the present information on medicinal use of plants may be used for botanical and pharmacological research in future for the discovery of new sources of drugs.
subject: Articles
  topic: section
subject: Pillur Beat
  topic: keywords
subject: Irulas
  topic: keywords
subject: Traditional medicine
  topic: keywords
subject: ethnobotany
  topic: keywords
creator: Dhivya S.M
creator: Kalaichelvi K
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 67
ending page: 77
doi: 10.30904/j.jpbr.2016.3242

Medicinal Plants Diversity in Kundri Hill T.N Palayam Range of Sathyamangalam Reserve Forest in Erode District, Tamil Nadu
type: item
description: The survey was carried out in Kundri hill area, it has documented a total of 75 angiospermic plants and one pteridophyte with medicinal value. Of these 75 angiospermic plants, 68 species are dicotyledons and 7 species are monocotyledons. Within the dicotyledons, 29 species are polypetalae, 34 species are gamopetalae and 5 species are monochlamydeae. Gymnosperms were almost nil. The angiospermic plants surveyed in the Kundri belong to 19 polypetalae families, 15 gamopetalae families, 6 monochlamydeae families and 5 monocotyledons families. In the present account 75 species of angiosperms and one fern are used as ethnomedicine for various disorders and diseases like piles, menorrhagia, epitaxis, alexipharmic, burns, disease of blood, throat disorders, chronic bronchitis, rheumatism, anaemia, asthma, nose and eye diseases, indigestion, dysentery, diarrheoa, dyspepsia, fever, vaginal infections, tumors, neuralgin, splenopathy, leucorrhoea, ulcers, muscular pain, rheumatoid arthritis, urinary problem, skin infections, eczema, painful swelling of joint, flatulence, cardiac disorders, oxytocic, cancer, leucoderma, diabetes, allergic rhinitis, hiccough, oedema, pruritus etc
subject: Articles
  topic: section
subject: Kundri hills
  topic: keywords
subject: Medicinal Plants
  topic: keywords
subject: Data collection
  topic: keywords
subject: Ethnobotany
  topic: keywords
creator: Vijayashalini P
creator: Anjanadevi N
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-12-21
publication date: 2016-12-21
starting page: 61
ending page: 66
doi: 10.30904/j.jpbr.2016.3125

A Comparative Safety and Efficacy Study of Olmesrtan, a Newer Angiotensin-II Type-1 Receptor Blocker in Early Stage Type–2 Diabetes with Hypertension
type: item
description: Patients with type-2 diabetes are at high risk for developing cardiovascular diseases, which are also the most common cause of death in these patients. Angiotensin II type-1 receptor blockers (ARB) are widely used for the treatment of hypertension. Among the several ARBs available in the clinical setting, olmesartan is thought to have a significantly stronger blood pressure lowering effect than losartan or valsartan with their respective starting doses. In addition, recent data demonstrated that olmesartan more adequately achieved ambulatory blood pressure monitoring (ABPM) goals during the early morning surge period than did candesartan. Considering the importance of strict blood pressure control, olmesartan offers certain advantages in clinical use. With regard to its metabolic effect, telmisartan has the unique property of selective peroxisome proliferation–activated receptor (PPARγ) modulating activity, at least in-vitro. Thus, telmisartan might have clinical effects similar to those of PPARγ agonists, such as improving insulin resistance and increasing serum adiponectin levels. In fact, a recent study demonstrated that replacement of valsartan with telmisartan reduced serum highly sensitive C-reactive protein (hs-CRP) and increased serum adiponectin. Another study revealed that telmisartan has superior effects on metabolic parameters compared to losartan in hypertensive patients with metabolic syndrome. In addition, telmisartan blood pressure lowering effect is reported to last longer than valsartan’s. To gain insight into the respective properties of ARB for type-2 diabetic patients with hypertension, an open-label crossover trial was conducted to compare the efficacy of the starting doses of olmesartan and telmisartan on blood pressure, and metabolic parameters. A clinical study has shown that a doses in patients with type-2 diabetes, olmesartan seems to have more potent blood pressure lowering than telmisartan, but similar effects on metabolic parameters. Ou…
subject: Articles
  topic: section
subject: cardiovascular
  topic: keywords
subject: diseases
  topic: keywords
subject: Angiotensin II
  topic: keywords
subject: olmesartan
  topic: keywords
subject: telmisartan
  topic: keywords
subject: hypertension
  topic: keywords
creator: Vijay Kumar Enugula
creator: Mohammed Yusuf Shaik
creator: Vara Prsanna Rao M
creator: Nagendra Prasad B
creator: Surya Savarny C
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-06-21
publication date: 2016-06-21
starting page: 18
ending page: 22
doi: 10.30904/j.jpbr.2016.2953

Evaluation of Cardioprotective Activity of Ethanolic Extract of Cordia sebestena Against Myocardial Infarction: A Comprehensive Review
type: item
description: Myocardial infarction (MI) remains one of the most prevalent and fatal cardiovascular disorders worldwide, primarily resulting from ischemia-induced oxidative stress, inflammation, and cardiomyocyte apoptosis. Although conventional pharmacotherapy has significantly reduced mortality, long-term usage is often associated with adverse effects, necessitating the exploration of safer cardioprotective agents. Medicinal plants rich in bioactive phytoconstituents have emerged as promising alternatives due to their multitarget therapeutic potential. Cordia sebestena L., belonging to the family Boraginaceae, is traditionally employed for the treatment of inflammatory and oxidative stress–related disorders. The ethanolic extract of Cordia sebestena is reported to contain flavonoids, phenolic compounds, tannins, saponins, and terpenoids, which possess potent antioxidant and anti-inflammatory properties. This review comprehensively evaluates the cardioprotective activity of the ethanolic extract of Cordia sebestena against myocardial infarction, focusing on its phytochemical profile, mechanistic pathways, experimental evidence, and future therapeutic prospects. The collective findings suggest that Cordia sebestena exhibits significant cardioprotective effects by attenuating oxidative stress, stabilizing myocardial membranes, modulating inflammatory mediators, and preventing cardiomyocyte apoptosis.
subject: Articles
  topic: section
subject: Cordia sebestena
  topic: keywords
subject: Myocardial infarction
  topic: keywords
subject: Cardioprotection
  topic: keywords
subject: Ethanolic extract
  topic: keywords
subject: Antioxidants
  topic: keywords
subject: Phytochemicals
  topic: keywords
creator: Lakshmi M
creator: Kumar B
rights: Copyright (c) 2016 Author https://creativecommons.org/licenses/by-nc/4.0/
date: 2016-06-21
publication date: 2016-06-21
starting page: 56
ending page: 60
doi: 10.30904/j.jpbr.2016.2986