Study of Effect of Various Polymers in the Formulation Development of Mucoadhesive Buccal Tablets of Propranolol HCL

Abstract

The release rate of Propranolol HCl from buccal tablets was found to be influenced primarily by the type and concentration of polymer used in tablet formulation. The controlled drug release following first-order kinetics demonstrated that hydrophilic matrix tablets prepared with Carbopol 934 and HPMC K100 are effective as buccoadhesive controlled-release delivery systems. Both pre-compression and post-compression evaluation parameters for all formulations were within acceptable limits. The matrix tablets formulated with HPMC K100 (Formulation F5) exhibited slow, controlled, and nearly complete drug release over 11 hours, achieving 93.45% drug release. These findings suggest that the selected polymers successfully regulate the release profile of Propranolol HCl in buccal delivery systems, ensuring sustained therapeutic effects.