Therapeutic strategies on Blood brain barrier

Abstract

BBB comprises different molecular components and transport systems, which in turn create efflux machinery or hindrance for the entry of several drugs in brain. It is a vital component of the neurovascular unit (NVU) containing tight junctional (TJ) proteins and different ion and nutrient transporters which maintain normal brain physiology. The blood-brain barrier (BBB) is responsible for much of this difficulty but also provides an essential separation from systemic circulation. Due to the BBB’s physical and chemical constraints, many current therapies, from cytotoxic drugs to antibody-based proteins, cannot gain access to the tumor. Various strategies are being developed to enhance the amount and concentration of therapeutic compounds in the brain.  The present review describes those different approaches of therapeutic strategies on blood brain barrier. These approaches are mainly utilized to overcome the brain tumors.