Development and Evaluation of Controlled-Release Matrix Tablets of Quetiapine Fumarate Using Hydrophilic Polymers

Abstract

The present study aimed to develop controlled-release matrix tablets of quetiapine fumarate using various hydrophilic polymers to prolong drug release and reduce dosing frequency. Matrix tablets containing quetiapine fumarate were prepared by direct compression using hydroxypropyl methylcellulose (HPMC K15M and HPMC K100M) and guar gum as release-retarding polymers. Precompression parameters including angle of repose, bulk density, tapped density, Carr’s index, and Hausner ratio were evaluated. The compressed tablets were assessed for hardness, friability, thickness, weight variation, drug content, and in vitro drug release. The powder blends exhibited satisfactory flow properties. All formulations complied with pharmacopeial requirements for post-compression parameters. Drug release studies were performed in 0.1N hydrochloric acid for 2 hours followed by phosphate buffer pH 6.8 for 6 hours. Among the formulations, F2 containing HPMC K15M exhibited sustained drug release of 97.3% over 8 hours and demonstrated desirable controlled-release characteristics. Formulations prepared with higher concentrations of HPMC K100M showed slower drug release, whereas guar gum formulations failed to provide the desired release profile. The study concludes that HPMC K15M is an effective polymer for developing controlled-release quetiapine fumarate tablets.