Formulation and Evaluation of Sustained Release Matrix Tablet of Fosinopril

Abstract

The study successfully developed sustained release tablets of Fosinopril using a validated UV spectrophotometric method for accurate drug quantification. The method showed a strong linear relationship within the tested concentration range, ensuring precise measurement. Solid dispersions with HP-β-cyclodextrin significantly enhanced the drug’s solubility and dissolution, with the kneaded complex achieving over 90% release within an hour. Pre-compression characterization indicated good flow and compressibility of tablet blends, essential for efficient manufacturing. Post-compression evaluations confirmed tablets had uniform weight, appropriate hardness, low friability, and consistent drug content, meeting pharmacopeial standards. In vitro studies highlighted a controlled and sustained drug release over 12 hours, governed by diffusion and erosion mechanisms. Overall, the formulations offer improved dissolution profiles and controlled delivery of Fosinopril, potentially enhancing therapeutic efficacy and patient compliance.