Prospective Study on Pattern of Adverse Drug Reactions to Anti-Cancer Drugs at a Tertiary Care Hospital

Abstract

Cancer is a very complicated sequence of disease conditions progressing gradually with a generalized loss of growth control. There were only a few options of cancer treatment for patients for many decades which include surgery, radiation therapy, and chemotherapy as single treatments or in combination. The present study aimed to assess pattern of adverse drug reactions to anti-cancer drugs at a tertiary care hospital. The prospective observational study was carried out for a period of 6 months. The study was conducted in Pediatrics department in a tertiary care hospital. Mouth organs affected cancer patients were more 24(32 %) as compared to Brain organs affected patients were 14 (18.66%). In our study Surgery treatment patients were more 34 (45.33%) as compared to other chemo therapy patients. Prescribed drugs during the cancer treatment includes Pemitrexate prescribed drugs patients were more 18(24%) as compared to other prescribed drugs 126-133. The anti-cancer drugs ADR includes Nausea and vomiting patients were more 34 (45.33%), compared to Alopecia patients were 25 (33.33%), Numbness and Constipation patients were 16 (21.33%). Epidemiological information on cancer including the pattern and socio-demographic factors is fundamental in determining the priorities for cancer control in the given population group. The cancer registries in India take into account only a representative sample of the whole country. This study shows that there is marked difference in the cancer pattern of our hospital in comparison with the national statistics. Hence factors leading to such high incidence should be analyzed and steps towards prevention of this type of cancer should be taken to reduce the morbidity and mortality of cancer. Further, more such research can be conducted all over the country to find the cancer pattern of different areas and thus pave the way for effective preventive measures.