Formulation and Assessment of Rapidly Disintegrating Tablets of Empagliflozin by Enhancing Dissolution Rate and Bioavailability

Authors

  • Sai Tharun T P Department of Pharmaceutics, KGR Institute of Technology and Management, Rampally (V), Keesara(M), Medchal, Hyderabad -501302 Author
  • Dr. V. Anjaneyulu Professor&HOD, Department of Pharmaceutics, KGR Institute of technology and Management, Rampally (V), Keesara(M), Medchal, Hyderabad -501302 Author
  • Dr. Vijay Kumar Gampa Principal& Professor, Department of Pharmacy, KGR Institute of technology and Management, Rampally (V), Keesara(M), Medchal, Hyderabad -501302 Author

DOI:

https://doi.org/10.30904/j.ijrpls.2025.4820

Keywords:

Empagliflozin, Mouth Disintegrating Tablets, Superdisintegrants, In Vitro Drug Release, Patient Compliance, UV Spectrophotometry

Abstract

This study developed and evaluated mouth disintegrating tablets (MDTs) of Empagliflozin to enhance patient compliance and rapid drug onset. Using UV spectrophotometry (λmax 225nm in 0.1NHCl), MDTs were prepared via direct compression with superdisintegrants SSG, Crospovidone, and Croscarmellose sodium. All formulations met pharmacopeial standards. Batch F-6 with Crospovidone showed the best performance, releasing 99% of the drug within 30 minutes. The findings confirm the effectiveness of a minimal-excipient, direct compression method for efficient Empagliflozin delivery.

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Published

2025-06-07

Issue

Vol. 13 No. 1 (2025): Volume 13, Issue 1, 2025

Section

Articles

License

Copyright (c) 2025 Author

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

T P, S. T., Dr. V, A., & Gampa, V. K. (2025). Formulation and Assessment of Rapidly Disintegrating Tablets of Empagliflozin by Enhancing Dissolution Rate and Bioavailability. International Journal of Research in Pharmacy and Life Sciences, 13(1), 31-37. https://doi.org/10.30904/j.ijrpls.2025.4820