Design and Development of Liquid Solid System of Poorly Soluble Drug (Class-II) to Improve Dissolution Rate

Abstract

The present study aimed to perform a comparative evaluation of natural polymers, namely Xanthan gum and Tragacanth, and to investigate the influence of the physico-chemical properties of the active ingredient on drug release behavior using the liquid-solid compact technique with PEG 400 and Tween 80 as non-volatile vehicles. Pre-compression parameters such as angle of repose, compressibility index, and sieve analysis indicated that the prepared formulations were suitable for the liquid-solid compact method. Tizanidine was successfully formulated into a sustained-release drug delivery system, demonstrating prolonged therapeutic action without reaching toxic plasma concentrations commonly associated with conventional dosage forms. This approach offers the potential to reduce dosing frequency and improve patient compliance. Drug release studies confirmed that the release followed first-order kinetics with the mechanism best fitting the Higuchi model. The findings of the in vitro release studies suggest that the developed sustained-release formulation is a promising candidate for further in vivo evaluations.