Formulation and Evaluation of Extended Release Matrix Tablets of Zopiclone by using Natural and Synthetic Polymers

Abstract

The objective of this study was to develop and evaluate extended-release matrix tablets of Zopiclone, a hypnotic agent, utilizing both natural and synthetic polymers to achieve a controlled drug release profile. Zopiclone, known for its efficacy in treating insomnia, requires a formulation that provides sustained release to improve therapeutic outcomes and patient compliance. Matrix tablets were formulated using various combinations of natural polymers (Tragacanth and Lactose Bean gumm) and synthetic polymers Carbopol-941P, PVP K30. The tablets were prepared by the direct compression method and evaluated for various parameters, including tablet hardness, friability, drug content, and in vitro drug release. The extended-release characteristics were assessed using dissolution testing, where the impact of different polymer combinations on the drug release rate was analyzed. The results indicated that the use of synthetic polymers, particularly Carbopol-941P, provided a more controlled and consistent release profile compared to natural polymers alone. A combination of natural and synthetic polymers achieved an optimal balance, ensuring a sustained release of Zopiclone over an extended period. The optimized formulations demonstrated desirable release kinetics with a controlled drug release extending up to 12 hours, aligning with the therapeutic needs for extended release. These findings suggest that a judicious selection and combination of natural and synthetic polymers can effectively tailor the release profile of Zopiclone, enhancing its clinical efficacy and patient adherence.