Formulation and Evaluation of Ornidazole Topical Emulgels

Abstract

This study focused on developing and evaluating Ornidazole-based emulgel formulations for topical use. A UV calibration curve confirmed the drug’s λmax at 335 nm, while FTIR and DSC verified its purity and stability with excipients. All formulations showed suitable pH (5.24–6.0) for skin application. Among them, formulation F3 exhibited the best spreadability, viscosity, and drug release (93.2% in 6 hours), along with the highest antimicrobial activity (48.48% inhibition). F3 also demonstrated good drug content uniformity and skin compatibility. Overall, F3 proved to be a promising topical delivery system for Ornidazole, warranting further clinical investigation.