Formulation, Evaluation and Optimization of Fast Dissolving Tablet of Zaltoprofen

Abstract

This study aimed at developing and evaluating fast oral disintegrating tablets of Zaltoprofen, supported by a validated UV spectrophotometric analysis for drug quantification. The method showed strong linearity in the concentration range of 2 to 10 µg/ml at an absorption peak of 257nm in 0.1 N HCl, ensuring precise and reliable detection. Pre-compression characterizations exhibited favorable powder flow and compressibility, indicated by consistent bulk and tapped densities, Carr’s index, Hausner ratio, and angle of repose values, facilitating smooth tablet manufacturing by direct compression. Post-compression evaluation confirmed that the tablets met quality control benchmarks including uniform hardness, low friability, consistent drug content, and appropriate thickness. The formulations demonstrated rapid disintegration and wetting times, essential for effective oral delivery. In vitro dissolution studies revealed efficient release profiles, with the optimal formulation achieving nearly complete drug release within 30 minutes. Further kinetic analyses confirmed a controlled drug release mechanism, fitting zero and first-order models. FTIR studies indicated no interaction between the drug and excipients, assuring formulation stability. Overall, the research successfully produced high-quality Zaltoprofen oral disintegrating tablets with rapid onset potential and stable composition, enhancing patient compliance and therapeutic efficiency.