Formulation, Optimization and Evaluation of Ritonavir Loaded Nano Emulsion

Abstract

The present study was undertaken to develop and evaluate nanoemulsion-based transdermal gel formulations of Ritonavir using different polymers. The formulations were systematically assessed through physicochemical and stability studies, including pH, weight/ml, assay, viscosity, sedimentation volume, ease of redispersibility, and particle size analysis. The results demonstrated that all evaluated parameters remained stable throughout the study, confirming the suitability of the developed formulations. Among the different batches, formulation F3 exhibited the most favorable properties, including stability, uniformity, pleasant texture, and good redispersibility. Dissolution studies further revealed that F3 achieved a maximum drug release of 98.89% within 10 hours, designating it as the optimized formulation. Additionally, formulation F8, containing D-Sorbitol at a concentration of 75 mg, was also prepared and evaluated. Overall, the findings highlight formulation F3 as a promising nanoemulsion-based transdermal gel for Ritonavir, offering enhanced drug release and stable characteristics for potential therapeutic application.