Formulation and Evaluation of Delayed Release Enteric Coated Tablets of Repaglinide

Abstract

This study focuses on the preparation& examination of SR tablets of Repaglinide. A CC graph of Repaglinide in KH2PO4 buffer 6.8 was established, showing compliance with in the conc. extent of 2 to 10 µg per ml, with a R² value of 0.999. Precompression investigation demonstrated good flow properties across all formulations, with bulk density, index of compressibility, & flow ability ratio of within acceptable limits. Post-compression evaluations showed that the tablets complied with USP standards, displaying consistent weight, thickness (3.93-4.15 mm), hardness (5.56-6.63 kg/cm²), and friability below 1%. Drug content was within the 98-102% range, ensuring uniformity. In vitro dissolution studies revealed significant sustained drug release, with formulations achieving 100% liberate within 12 hours. Kinetic modeling indicated a combination of 1^st-order and Higuchi release mechanisms. The R² values extent from 0.812 to 0.979, & Peppas plots suggested diffusion and erosion-controlled release in most formulations, making these SR tablets suitable for therapeutic use.