Solubility Enhancement and Formulation of Lovastatin Self Emulsifying Drug Delivery System

Abstract

Self‐emulsifying formulations spread readily in the gastrointestinal (GI) tract, and the digestive motility of the stomach and the intestine provide the agitation necessary for self-emulsification. These systems advantageously present the drug in dissolved form and the small droplet size provides a large interfacial area for the drug absorption. Hence in the present research a novel dosage form of liquid SMEDDS of Lovastatin was formulated and developed to enhance their solubility and dissolution, which may enhance the oral absorption and therapeutic performance of drug. From pseudo ternary PD, highest microemulsion zone found was at Smix ratio (4:1). From pseudo ternary diagram, quantitative selection of vehicles was done and liquid SMEDDS formulations of lovastatin were prepared (L1 to L5) by varying concentration of oil and Smix. The SMEDDS L2 showed high negative zetapotential near to range, homogenous globule distribution (from PDI), smaller droplets, high %T and % drug content. L2 showed drug release of 99 % whereas pure drug showed 30.5 % at 30 min in pH 1.2. L2 showed drug release of 99 % whereas pure drug showed 54.9 % at 30 min in pH 7.0 buffer with SLS, L2 showed drug release of 98.9 % whereas pure drug showed 33.92% at 30 min in pH 7.0 buffer without SLS, which indicate drastic improvement in drug release from liquid SMEDDS L2 in comparison to pure drug.