Formulation and In-Vitro Evaluation of Taste Masked Fast Disintegrating Tablet Rosuvastatin Calcium

Abstract

The present study was aimed at developing oral disintegrating tablets (ODTs) of Rosuvastatin with enhanced solubility and rapid disintegration using a simple and cost-effective method. A suitable UV-Visible spectrophotometric method was established for drug analysis, with λmax identified at 220 nm in phosphate buffer pH 6.8. ODTs were successfully formulated by direct compression technique utilizing pregelatinized starch, banana powder, and corn starch as natural and conventional excipients. All prepared formulations were evaluated for hardness, friability, weight variation, and drug content, and the values were found to be within acceptable limits, confirming good quality and reproducibility. In vitro drug release studies indicated that formulation F3 exhibited the best performance, showing superior release characteristics compared to other batches. Notably, formulations containing banana powder demonstrated enhanced drug release compared to those with other excipients. Overall, the study successfully achieved its objective of formulating Rosuvastatin ODTs using minimal excipients and a simple manufacturing approach, ensuring improved solubility and patient compliance.