Formulation and Development of Floating Tablets of Nizatidine

Abstract

This study focused on the development and evaluation of floating tablets of Nizatidine designed to prolong gastric retention and achieve sustained drug release. A UV-Visible spectrophotometric method was validated for drug quantification using 0.1N HCl as the solvent with absorbance measured at 242 nm, showing excellent linearity and precision within 2 to 10 µg/ml concentration range. The pre-compression evaluation of powder blends revealed consistent bulk and tapped densities, favorable flow and compressibility properties as indicated by Carr’s index, Hausner ratio, and angle of repose, suitable for direct compression.Post-compression studies confirmed tablet formulations met pharmacopeial requirements for hardness, friability, drug content, thickness, and weight uniformity, ensuring mechanical robustness and dosage accuracy. In vitro buoyancy tests demonstrated rapid floating onset and maintained buoyancy up to 12 hours with matrix integrity intact. The dissolution profile highlighted efficient, sustained drug release, with the optimal formulation displaying a release mechanism consistent with diffusion-controlled, non-Fickian behavior, as supported by kinetic modeling. Overall, the research successfully formulated gastroretentive Nizatidine floating tablets with enhanced gastric residence, controlled release characteristics, and potential for improved therapeutic efficacy and patient adherence.