A Review on Transdermal patch loaded with capecitabine nanopaticles used for breast cancer therapy

Abstract

Nanoparticle based drugs are an advanced approach in Cancer treatment using nanoscale particles to deliver drugs more effectively to cancer cell. While minimising damage to healthy cells. Nano particles typically range from 1to 100 Nanometre in size. Breast Cancer is a Leading Cause of Cancer - related deaths in women. To address these challenges, we developed a nanoparticle Mediated Capecitabine transdermal patch for targeted breast Cancer therapy. Polymeric nanoparticles Loaded with Capecitabine Were prepared using Solvent Evaporation method and characterized for size, Morphology, and drug release. Compared to oral capecitabine, the Novel delivery system offers a promising approach for Enhance breast cancer therapy, with potential for improve patient outcomes and quality of life. The Nano particles, Were then incorporated into a transdermal patch, which was Evaluated for in vitro skin permeation pharmacokinetics. Results showed enhanced skin permeation and controlled drug release leading to increased bioavailability and reduced toxicity.