Formulation of Antiseptic Ointment from Mangifera Indica Seed and Leaf Powder Extracts

Abstract

Background:  Ointments are semisolid dosage form which usually actasvisco-elasticmaterials when shear stress is applied. They generally contain medicinal ingredients and are used to be applied externally to the body for therapeutic effect. Aim: Medicinal plant parts and extracts have been the focus of several researches. This is because there is increasing need to develop novel therapeutic and pharmaceutical products as alternatives to synthetic products. Materials and Methods: Mangifera indica, commonly used herb in ayurvedic medicine. Although review articles on this plant arealready published, but this review article is presented tocompile allt heupdated information on its phytochemical and pharmacological activities, which were performed widely cardiotonic , hypotensive, anti-inflammatory properties. Results and Discussion: Various studies have been conducted on extracts obtained from leaves, fruit peel, root, stem bark and seed kernel of M. indica to ascertain their antimicrobial activities. Quantity of extracts and quantity of phytochemicals in a particular extract are dependent on a number of factors which include type of solvent used, extraction method, seasons and environmental conditions. Conclusion: This study shows that MI has high potential as antimicrobial agent when formulated as ointment for topical use and could, therefore, explain the successes claimed in the folk use of the plant in the treatment of common skin conditions. Among the Prepared Formulation Batches, F5 showed the higher zone of inhibition against S. aureus, C. albicans, E. coli, M. smegmatis. Formulation F1, F2, F3, F4 of Ointment have lesser zone of inhibition compared with F5 ointment.