In-Vitro and In-Vivo Evaluation of the Antidiabetic Potential and Antioxidant Properties of Selected GS Extract in DIO Mice Model

Abstract

Diabetes mellitus (DM) is a persistent metabolic disorder marked by elevated blood glucose levels (hyperglycemia), arising from impaired insulin secretion, defective insulin action, or a combination of both. It is one of the most prevalent non-communicable diseases globally and is considered a major public health challenge of the 21st century. This study was undertaken to evaluate the antidiabetic and antioxidant potential of the methanolic extract of Gymnema sylvestre through both in-vitro and in-vivo approaches, with particular emphasis on the DIO mouse model. The findings clearly demonstrate that the extract exhibits significant hypoglycemic, hypolipidemic, and antioxidant activities, thereby supporting its ethnopharmacological relevance in the management of diabetes mellitus. Overall, the Gymnema sylvestre extract appears to work through multiple pathways it slows sugar absorption, enhances antioxidant defenses, and protects key organs. Its effectiveness was comparable to the diabetes drug metformin, making it a promising natural option for managing diabetes.