Formulation and Evaluation of Metoprolol Succinate Buccal Adhesive Tablets Using Natural Polymers

Abstract

Buccoadhesive tablets were formulated using an active drug and mucoadhesive polymers to prolong drug residence in the buccal cavity, with mannitol incorporated to mask the drug’s taste; in this study, Metoprolol succinate was selected as the model drug, and both natural (NBA01, NBA02, NBA03, NBA04) and synthetic polymers (HPMC K100M, Eudragit RS100, Poloxamer 407) were evaluated. The natural polymers were characterized for phytochemical constituents, swelling index, particle size distribution, derived properties, moisture content, pH, and microbial load, and were found satisfactory for formulation development. Buccal tablet formulations were prepared as MNF1–MNF4 (NBA01), MNF5–MNF8 (NBA02), MNF9–MNF12 (NBA03), and MNF13–MNF16 (NBA04), while synthetic polymer-based formulations were prepared as MSF1–MSF3 (HPMC K100M), MSF4–MSF6 (Eudragit RS100), and MSF7–MSF9 (Poloxamer 407). Compatibility studies confirmed no significant interactions between drug and polymers, and both precompression and postcompression parameters were within acceptable limits, indicating suitability of the developed formulations for further evaluation.