Formulation and Characterization of Transferosome Transdermal Patch of Hydrochlorthizide

Abstract

Hydrochlorothiazide transdermal patches offer a promising alternative to oral delivery, aiming for sustained therapeutic effects and improved patient compliance. Accurate drug quantification and stability within the formulation are essential for effective development. A UV-Visible spectrophotometric method was developed and validated to quantify Hydrochlorothiazide in pH 7.4 phosphate buffer, measuring absorbance at 229 nm. Compatibility between the drug and polymers was assessed using FTIR spectroscopy. Various transdermal patches were prepared via solvent casting and evaluated for thickness, weight uniformity, drug content, folding endurance, and tensile strength. In vitro drug release was monitored over 12 hours, and release kinetics were modeled to understand the drug release mechanism. Stability studies were conducted over three months under accelerated conditions. The spectrophotometric method showed strong linearity and precision. FTIR analysis confirmed the drug's stability in the polymer matrix. The patches demonstrated consistent physical and mechanical properties suitable for transdermal delivery. Drug release studies revealed sustained and near-complete release, fitting diffusion-controlled models, primarily the Korsmeyer-Peppas model. Stability tests indicated no significant changes in drug release profile or physical parameters over three months. Hydrochlorothiazide transdermal patches were successfully formulated with desirable mechanical strength, controlled drug release, and stability, suggesting their potential as an effective and patient-friendly therapeutic alternative.