Development and Validation of new analytical methods for the estimation of Lacosamide by UV Spectroscopy

Abstract

A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of Lacosamide in bulk and its pharmaceutical formulation. The method was validated as per International Conference on Harmonization [ICH] guidelines. The Lacosamide was monitored at 230 nm with UV detection and there is no interference of diluent at 230 nm for lacosamide. The method was linear (r²=0.999) at concentration ranging from 12 to 40μg/mL, precise (intra and inter-day RSD values < 1.0%), accurate (mean recovery = 99.9%), specific and robust. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of lacosamide in bulk and tablet dosage forms.