Development and In-vitro Characterization of Gastro Retentive Floating Tablets of Nefidipine Using Various Polymers

Authors

  • B. Sindhura CVM college of Pharmacy, Karimnagar, Telangana, India Author
  • Gampa Vijaya Kumar Professor & Principal, CVM College of Pharmacy, Karimnagar, Telangana, India Author
  • Vijay Prakash Assistant professor, CVM college of Pharmacy, Karimnagar, Telangana, India Author
  • K. Someshwar Managers, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad, Telangana, India Author

DOI:

https://doi.org/10.30904/

Keywords:

Nifedipine, Guar gum, Chitosan, Sodium CMC, sustained release tablets

Abstract

The aim of the present study was to develop sustained release formulation of Nifedipine to maintain constant therapeutic levels of the drug for over 12 hrs. Various natural polymers such as Guar gum Sodium CMC and Chitosan were employed as polymers. Nifedipine dose was fixed as 50 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 60, 90 and 180 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F3) showed better and desired drug release pattern i.e., 97.30 % in 12 hours. It followed zero order release kinetics mechanism.

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Published

2015-06-29

Issue

Vol. 2 No. 01 (2015): WJPBT

Section

Articles

License

Copyright (c) 2015 Author

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

B, S., Gampa, V. K., Prakash, V., & K, S. (2015). Development and In-vitro Characterization of Gastro Retentive Floating Tablets of Nefidipine Using Various Polymers. World Journal of Pharmacy and Biotechnology, 2(01), 20-25. https://doi.org/10.30904/