Design, Development and In-vitro characterisation of Metolazone Fast Dissolving Tablets Using Various Super Disintegrants

Abstract

In the present work, an attempt has been made to develop fast dissolving tablets of Metolazone. In the present work Sodium starch glycollate, Cross povidone and Cross carmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F9 formulation showed maximum % drug release i.e., 98.54 % in 30 min hence it is considered as optimized formulation. The F9 formulation contains CP as super disintegrate in the concentration of 15mg.