Observation on Depression Relieving Properties of Hydro Alcoholic Extracts of Aniba Riparia in Experimental Mice

Authors

  • Sravanthi R KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. Author
  • Y.Sridhar Professor, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. Author
  • Vijaya Kumar Gampa Professor and Head, Dept. of Pharmacy, KGR Institute of Technology and Management, Rampally, Kesara, Rangareddy, Telangana, India. Author

DOI:

https://doi.org/10.30904/

Keywords:

Aniba riparia, antidepressant activity

Abstract

In the present study, Aniba riparia significantly increased the frequency of 5-HTP induced head twitches, Clonidine induced aggression and L-DOPA induced hyperactivity and aggressive behavior indicating its enhanced activity on serotonergic, noradrenergic and dopaminergic pathways respectively. Our results also confirm the involvement of serotonergic, noradrenergic and dopaminergic pathways in depression. Pretreatment with Aniba riparia. Results from behavioral experiments indicate that the antidepressant activity of Aniba riparia, might be due to the facilitatory effect on serotonergic, noradrenergic and dopaminergic systems apart from the antioxidant activity. The results from the present study confirm the antidepressant activity of Aniba riparia, since it reduced the immobility in both FST and TST.

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Published

2019-12-29

Issue

Vol. 6 No. 02 (2019): World Journal of Pharmacy and Biotechnology

Section

Articles

License

Copyright (c) 2019 Author

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

R, S., Y, S., & Gampa, V. K. (2019). Observation on Depression Relieving Properties of Hydro Alcoholic Extracts of Aniba Riparia in Experimental Mice. World Journal of Pharmacy and Biotechnology, 6(02), 43-47. https://doi.org/10.30904/