Formulation and In-Vitro Evaluation of Topical Emulgel of Phenyl Benzoate by Using Different Polymers

Abstract

The objective of the present investigation was to formulate and in vitro evaluation of topical emulgel of phenyl benzoate by using different polymers. Topical drug administration is simplest and easiest route of localised drug delivery anywhere in the body by routes as ophthalmic, rectal, vaginal and skin. Phenyl Benzoate binds to and inactivates prostaglandin H synthase through peroxide mediate deactivation then reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. Twelve formulations of topical emulgel was preparing the emulsion and its jellification by mixing with the gel solution with polymer such as Carbapol 934, Tween-80, Span-80, ethanol, methyl paraben, propyl paraben,  HPMC, wheat germ oil and thyme oil in different ratios. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, spreadability, consistency and viscosity.  Out of all the formulation developed formulation F3formulation to show the highest value when compared to other formulations.