Formulation and Evaluation of Mouth Dissolving Tablets of Hydroxyzin Hydrochloride

Abstract

The objective of the present investigation was to formulate and evaluate of mouth dissolving tablets of Hydroxyzine hydrochloride. Mouth dissolving tablets of Hydroxyzine hydrochloride will dissolve in the patient mouth without need of water or chewing and release its drug contents instantaneously. So this dosage forms more comfortable for paediatric patients. Tablets were prepared direct compression method using Crospovidone Sodium starch Glycolate and croscarmellose sodium as super disintegrants, Orange Flavour were used as sweetening agents. The tablets were evaluated for weight variation, hardness and friability data indicated good mechanical strength of tablets. The results of in –vitro disintegration time indicated that the tablets were dispersed rapidly in the mouth with in 3.84minutes. It was concluded that mouth dissolving tablets of Hydroxyzine hydrochloride